The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity
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The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity
Chordin-mediated regulation of bone morphogenetic protein (BMP) family growth factors is essential in early embryogenesis and adult homoeostasis. Chordin binds to BMPs through cysteine-rich von Willebrand factor type C (vWC) homology domains and blocks them from interacting with their cell surface receptors. These domains also self-associate and enable chordin to target related proteins to fine...
متن کاملNanoscale structure of the BMP antagonist chordin supports cooperative BMP binding.
Bone morphogenetic proteins (BMPs) orchestrate key cellular events, such as proliferation and differentiation, in development and homeostasis. Extracellular antagonists, such as chordin, are essential regulators of BMP signaling. Chordin binds to BMPs blocking interaction with receptors, and cleavage by tolloid proteinases is thought to relieve this inhibition. A model has been previously propo...
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15 صفحه اولStructural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway
Twisted gastrulation (Tsg) and chordin are secreted glycoproteins that function together as BMP (bone morphogenetic protein) antagonists to regulate BMP growth factor signalling. Chordin binds to BMPs, preventing them from interacting with their receptors and Tsg is known to strengthen this inhibitory complex. Tsg also acts as a BMP agonist by promoting cleavage of chordin by tolloid-family pro...
متن کاملTwisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.
BMP signaling is modulated by a number of extracellular proteins, including the inhibitor Chordin, Tolloid-related enzymes (Tld), and the interacting protein Twisted Gastrulation (Tsg). Although in vitro studies have demonstrated Chordin cleavage by Tld enzymes, its significance as a regulatory mechanism in vivo has not been established in vertebrates. In addition, Tsg has been reported in diff...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2015
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20150071